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Cytochrome P450 Inhibition: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas Cytochrome P450 Inhibition Because of the important role of Cytochrome p450 enzymes in drug metabolism, it is important to assess the ability of lead compounds to inhibit specific cytochrome p450 enzymes to avoid

Nikon CSU-W1 SoRa: Quantitative Light Microscopy Core Facility - UT Southwestern, Dallas, Texas Nikon CSU-W1 SoRa (NL5.120R) Spinning disk confocal microscope for viewing rapid dynamics in live cells and tissues SoRa module for resolution down to 120 nm. Piezo z-drive for fast z-stack acquisition.

1 SBL Vitrobot Protocol (based on the Hibb’s lab protocol, modified by Xiaochen and James) Materials Required (your own supply or from SBL): - Grids. - Vitrobot Tweezer Assembly.

Subcutaneous Human Tumor Xenografts: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas Subcutaneous Human Tumor Xenografts The Preclinical Pharmacology Core has data and experience with testing efficacy of compounds in a modest number of human tumor cell lines implanted as subcutaneous xenografts

ClincialTrials.gov Education -UTSW-HRPP Human Research Protection Program Micro Navigation UTSW IRB sIRB Participants QA/Monitoring Regulatory Support Reportable Events News ClinicalTrials.gov Support Education and Trainings Sponsor Investigator (SI) Support ClincialTrials.gov Education ClincialTrials.gov

Mate-Paired - Next Generation Sequencing Core - UT Southwestern, Dallas, Texas Mate-Paired Samples are run on a 1.2% agarose gel and their concentrations quantified by fluorometry. Four µg of genomic DNA are processed using the Nextera Mate Pair Sample Preparation Kit from Illumina.

Exome Capture - Next Generation Sequencing Core - UT Southwestern, Dallas, Texas Exome Capture   Current Protocol Twist Past Protocols SureSelect XT v4 Sample Preparation Guide Instructions for Performing the Nextera Rapid Capture Protocol TruSeq Sample Enrichment Guide Ready to submit samples?

M KT 8 96 _0 3 Qualified participants must be: • Between age 18–70 years • South Asian or European Americans • Male and Female • Able to attend two visits • Persons taking medications for diabetes, heart disease or chronic health issues may not qualify For more information 214.648.9014

If there are missing documents or if further information is required that is necessary to accept reliance, the HRPP Analyst will contact the Principal Investigator (PI) and/or Research Coordinator.

$31.00 $46.50 24‐well crystallization tray (VDX) 15‐well crystallization tray (Nextal/Qiagen) 24‐well crystallization tray (Cryschem) Safematic compact coating unit training Talos Arctica usage, unassisted, hourly Titan Krios usage, unassisted, hourly Manuscript Preparation Synchrotron Data Collection